Bruno Costa-Silva
During his PhD, Bruno Costa-Silva (orcid.org/0000-0002-5932-6211) contributed to projects that
found that the interaction between Prion Protein and its ligand HSP70/HSP90 Organizing Protein induces colorectal cancer cells migration and invasion, nervous system stem cell self-renewal and development, glioblastoma growth and exosome production. He played a key role in the first publication to show how tumor exosomes induce the formation of pre-metastatic niches. During my post-doc, he first-authored the first work to identify the detailed mechanism of hepatic pre-metastatic niches formation by pancreatic cancer exosomes. He also participated on the first description of genomic double-stranded DNA packaging in tumor-derived exosomes and co-first authored a work that introduced the molecular basis of how tumor-derived exosomes form pre-metastatic niches in specific organs. As a group leader at Champalimaud Foundation he maintains productive collaborations with our Clinical Center and other European institutions. His research group focuses on the identification of new biological functions of EVs in oncologic settings and in the identification of circulating exosomes populations linked to incidence and prognosis of oncologic and non-oncologic diseases. http://neuro.fchampalimaud.org/en/research/investigators/research-groups/group/Costa- Silva/ |